Senior Scientist, Protein Engineering and Novel Modalities, Biologics Engineering, Oncology R&D
AstraZeneca

Senior Scientist, Protein Engineering and Novel Modalities, Biologics Engineering, Oncology R&D

We are seeking to recruit a highly motivated scientist to enhance our multispecific antibody platform technology efforts. The successful candidate will be excited by research at the interface where innovative technology meets Biology.

BUSINESS AREA

Biologics Engineering is responsible for the discovery, design, engineering, and optimization of next generation biologics to create biological drug candidates for all key therapeutic areas including oncology, respiratory and inflammation, cardiovascular, and renal and metabolic diseases. The Protein Engineering & Novel Modalities team designs, engineers, and optimizes bi/multi-specific antibody therapeutics through structure-function principles while collaborating broadly across the AZ Research organization. We're pushing the boundaries of science to deliver life-changing medicines to patients, with a passion for the development of novel drug modalities to address unmet medical needs.

What you'll do

• Lead collaborative workstreams with a diverse group of scientists across all therapeutic areas to ensure timely progress in research projects and drive technological innovations.
• Conceive, design, and execute the engineering of innovative multispecific antibodies with improved selectivity and developability
• Biochemical, biophysical and functional characterization of antibodies and multispecific modalities
• Prepare, analyze, and present data internally and externally

Education & Experience Requirements:

• PhD + 2-4 years of experience in Chemical or Biological Engineering, Biotechnology, Molecular Biology, Biochemistry or other relevant scientific field with experience in protein engineering and/or bispecific antibody technologies

Essential for the role

• Extensive hands-on experience in molecular biology and antibody/protein engineering, including; design, expression, purification and biochemical/biophysical characterization of various bispecific antibody formats
• Proven ability to work independently, effectively plan and organize work activities and prioritize task completion to meet project deadlines
• Deep understanding of various imaging/multicolor flow cytometry-based instruments and data analysis programs
• Comprehensive experience in tissue culture techniques and functional cell-based assay development
• Demonstrated experience in optimizing/troubleshooting protocols with a problem-solving mindset
• Track record of scientific innovation as evidenced by scientific publications, patents and oral presentations at conferences

Desirable for the role

• Understanding of protein and antibody structure-function relationships
• Experience in engineering antibodies with improved properties (e.g., affinity, solubility, and other attributes related to developability)
• Experience with bispecific therapeutics, e.g. T-cell engagers, ADCs, checkpoint inhibitors
• Background in antibody discovery using one of several display-based technologies
• Excellent written and verbal communication skills and effective presentation of complex scientific data to cross-functional and senior management

Why AstraZeneca?

At AstraZeneca when we see an opportunity for change, we seize it and make it happen, because any opportunity no matter how small, can be the start of something big.

So, what's next?

Are you already inspiring yourself joining our team? Are you ready to bring new insights and fresh thinking to the table? Good, because we can't wait to hear from you!

AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorization and employment eligibility verification requirements.

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